The subway is the best way around town. We bought a 7 day pass and really got our moneys worth. The only issues were going to and from the airport (JFK). It seemed that on the weekends, many lines are having service done to them. You will see some postings but they are not always clear.
The only other issue will be the card readers in some of the stations. Keep your card as flat as possible. Either put it in your purse or wallet. If you keep it in your pocket and it develops a crease, you could have problems. Ask for a subway map when you buy your pass.... it's great to have.
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