According to forum posts, there are regular bus services from Skopje to several nearby cities. For instance, there are buses to Istanbul, operating mainly via Greece, with specific departure information available from Rule Tours. Additionally, for travel between Skopje and Ohrid, users have discussed both bus and rental car options, with buses being a straightforward choice for those preferring public transportation.

Some travelers mentioned the availability of train services for certain routes, such as from Skopje to Bitola. This provides an alternative to bus travel for those routes where train services are operational.

Travelers have called out the flexibility provided by renting a car, especially for exploring scenic routes and making stops at attractions like Mavrovo National Park and various monasteries between Skopje and Ohrid. This option is preferred by those looking for freedom in their travel schedule and itinerary.

For routes lacking direct bus or train services, such as Skopje to Thessaloniki, some users have resorted to using private drivers or exploring other less conventional travel options, emphasizing the need to plan for such routes in advance.

According to forum posts, travelers recommend visiting historical and cultural sites such as St. Pantelejmon Church on Vodno Mountain, known for its ancient frescoes, and the Sultan Murat Mosque, which offers a glimpse into the Ottoman influence in the region. Additionally, the National and Ethnological Museum of Macedonia is praised for its extensive display of national costumes.

Some travelers mentioned exploring local markets and neighborhoods for a more immersive experience. The Old Bazaar and Bit Pazar, a flea market, are popular for experiencing the local hustle and bustle. For a unique local taste, visiting small coffee shops in the bazaar where Turkish coffee is brewed in hot sand is highly recommended.

Forum posts suggest that architecture enthusiasts should not miss the Brutalist buildings scattered around Skopje. Additionally, the Roma settlement of Shutka is noted for its unique cultural experience, offering a different perspective on local life in Skopje.