The main airport that serves Puerto Rico is Luis Munoz Marin International Airport, located in San Juan. A number of major airlines provide direct service to San Juan from several United States and international gateways. Several rental car agencies have service desks in the airport terminal or you can choose to rent a car in one of the larger cities such as San Juan.

Mayaguez is located 102 miles west of San Juan. Drive-time is just over two hours. Directions from San Juan are pretty straight forward -- basically just drive west til you hit the coast, then turn south into Mayaguez.