San Miguel Allende is a museum in itself. The mix of indigenous cultures (toltecas, guamares, pames, chichimecas and otomies) and the Spanish who arrived in the 16th century is reflected in the architecture where the colonial style is blended with ancestral and indigenous features.

The town boasts some museums that introduce the visitor to the history and the arts of the region. Located at the intersection of Umaran and Cuna de Allende streets, the Historical Museum of San Miguel Allende is a historical building where Ignacio Allende, one of Mexican promoters of independence from Spain, was born and grew up. The museum is organized on a history timeline beginning with prehistoric times and the first settlements on the shores of Laja river to Hispanic rule, the struggle for independence and the first years as an independent country. It is open every day except Monday from 09:00 to 17:00.Admission: about $3 usd. It reopened in April 2009, following renovations.

Other museums in town are the Banamex Museum and the Museum of Mexican Toys. Outside town are the pre-Hispanic pyramids known as Cañada de la Virgen.

Just north of town, a ten-minute taxi ride, is a large gallery of Mexican Folk Art, country antiques, and old photographs in a spectacular country setting (Galeria Atotonilco) with a beautiful restaurant next door (Nirvana) and an historically important, World Heritage Site church within a mile (the church at Atotonilco.)

Other historical buildings are the Centro Cultural Ignacio Ramirez El Nigromante, known as Bellas Artes, and the Instituto Allende, both are constructions from the 18th century of immense beauty.

Visit the Charco del Ingenio Jardin Botanico.The region is known for its extensive and varied collection of cactus, and this botanical garden reflects that, housing more than 1,000 varieties. It is open every day from 10:00 am to 5:00 pm. Admission charge.