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Visitors to Prague will have a lot of options when looking for ways to pass the time in the evening hours. The variety of options is growing, but it is still not a city that can match Paris or London. But that can be a good thing -- in terms of price, crowds, and more.
There are a number of sophisticated cocktail bars in the center of Prague. Batalion Comics Bar, on 28.rijna 3, close to Můstek metro station, is decorated with comic strips from the Czech comics painter Kája Saudek, which is something you won´t find nor see anywhere else in Europe. Tretter's, near Old Town Square, has a classic atmosphere, with a well-trained and customer-friendly bar staff. Also in the area are Zapa Bar and Bugsy's. Behind the Tyn Church on Old Town Square, there is Tynska Bar and Books.
Close from the Old town square don't miss the Cilibar, (Take the street Melantrichova and turn first left. The Cili bar situated in Kozna 8. They serve the best cocktails in Prague for the lowest prices. A small, cosy, a little smoky but nice bar will capture you for hours. And you will taste the best Daiquiri ever.
If you want to mix some dancing with your drinking and eating, there is Solidni Nejistota, a few blocks behind the National Theater. There is also La Fabrique, near Wenceslas Square. For something even more Czech-oriented, try Meloun also near Wenceslas Square.
There are some serious discos in Prague. Radost FX, behind I. P. Pavlova Square has many visiting star DJs for the dance floor downstairs. Upstairs, is a hip lounge and a vegetarian restaurant. Karlovy Lazne is a mega club near the Charles Bridge, with three different dance floors on different levels. There can be a long line here along the Vltava river in warmer months. On Wenceslas Square, there is an elevator entrance that will take you up to the club, Duplex. Mick Jagger had his 60th birthday party here while the Stones were touring.
Perhaps this sounds like a contradiction, but for a generally younger crowd, there is 80s and 90s night Fridays and Saturdays at Lucerna Music Club on Wenceslas Square. This is a fairly large club and it regularly fills to capacity. Another favorite of young people is M1 Secret Lounge on Masna, near Old Town Square. The crowd is generally a mix of well-off young Czechs and expat students.
For some less commercial dancefloors, try Palác Akropolis in Žižkov, which hosts a mix of live bands and DJs across a range of styles from drum and bass to funk to reggae; Chapeau Rouge on Jakubská street in New Town, and Cross Club, next to Nádraží Holešovice, which is a haven of underground dance music and a work of art in itself.
For blues and/or jazz, some good performances can be caught at U Maleho Glena, near Malostranske Namesti. The performance area is very small with just a few tables. You might want to check the performance schedule on the Internet and book ahead if you can. The same goes for Ungelt Jazz and Blues club, behind the Tyn Church.
Other places that are good for hanging out and drinking great beer with your food are: Pivovarsky Dum on Jecna, near Wenceslas Square, U Vejvodu near Narodni Trida, and the historic 500 year-old brewery, U Fleku, near Karlovo Namesti and Narodni Trida. Waiters walk around with trays full of shots to offer to customers, but you should know they don't do it out of kindness. They will be on your bill later. You should also be aware that you will pay over double the price for these drinks that you would pay anywhere else. For an authentic Czech experience, try Lokál restaurant on Dlouhá street, which serves tank beer and food and is very popular with Prague locals.
The side streets near Wenceslas Square are full of strip clubs. This is Prague's red light district. Pickpockets can be a problem in this area at night (often women who run up to groups of men asking for a hug, etc.) But it should be noted by all that pickpockets are a serious problem all over Prague, especially on public transport and crowd situations.
Travelers should change their money in the daytime through their hotel or a local bank and avoid the kiosks along Wenceslas Square at night because the commissions are outrageous.
Also remember that the metro closes at midnight.