The nearest airport to Binghamton is the Greater Binghamton Airport , located 8 miles outside of the city. A number of commuter airlines serve the airport, including U.S Airways Express, United Express, and Northwest Airlink.  Flights provide service between Binghamton and major cities such as Detroit, Philadelphia,  Washington, D.C. 

The nearest major airport to Binghamton is located in Syracuse, which is located 72 miles from Binghamton. All major airlines provide service to Syracuse Hancock International Airport . Several car rental agencies have desks inside the terminal, including Enterprise, Hertz, National, and Avis, among others.

Driving to Binghamton is relatively straightforward. The city is located at the crossroads between Interstate 81, which runs north-south, and Interstate 88, which runs east-west.  

Binghamton is also accessible by bus. The local Greyhound station is located at 81 Chenango Street.