For an island of its size, not to mention remoteness, Kamuela features a robust cultural scene that includes theater and musical concerts. The Kahilu Theater Foundation, which celebrated its 25th anniversary in 2005, is a non-profit arts organization that sponsors live performances in the 500-seat Kahilu Theatre in the South Kohala District, as well as independent film, youth programs and other local events.

The island is also home to the Waimea Community Theatre, which was founded in 1964 and is bbased in Waimea. This is home for community-sponsored plays, classical and jazz concerts and other workshops for the community. Concerts and events are held at the Parker School Auditorium and the Kahilu Theatre, as well as other venues across the big island.

Waimea is also home to the Waimea Consort, an a capella vocal ensemble that was founded in 1999. The group was formed to bring the tradition of medieval, renaissance, baroque and 20th century a caplla music to Hawaii, and this includes two main programs each year, along with other performances throughout the year on the big island.

The Kamuela Philharmonic is a professional orchestra featuring mostly Big Island musicians.  Under the direction of Dr. Madeline Schatz, the orchestra has three concerts per year.  In addition, it performs at the close of the Kona Coffee Festival in Kailua-Kona and presents an annual children's concert.  The season and children's concerts are all performed at the above-mentioned Kahilu Theatre.  Concerts are free; donations are accepted.

Each summer Hawaii Performing Arts Festival brings together faculty of performers, directors and teachers with a select group of aspiring music students from all over the world for an intense study and performance program. Students are closely coached as they prepare to participate in Hawaii Performing Arts Festival’s series of Masterclasses, concerts, recitals, and staged productions. While based in Waimea, there are HPAF performances throughout the Big Island, including many free events.